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Health Sciences; Natural Sciences and Engineering

Léa Harrington

Homéostasie de la longueur des télomères et instabilité génomique

Professeure titulaire

Faculté de médecine - Département de médecine

lea.harrington@umontreal.ca

Profile

Research expertise

Lea Harrington and her colleagues pursue the mechanisms by which chromosome ends, telomeres, are maintained and protected from degradation and recombination. The activity of an enzyme responsible for new telomere addition in most eukaryotes, telomerase, is increased in many cancers and conversely is decreased in many somatic tissues. Since critically short telomeres that elicit a DNA damage response are incompatible with cell viability, the regulation of telomerase activity and dosage is thus a critical determinant of normal and cancer cell proliferation.

Affiliations and responsabilities

Teaching and supervision

Projects

Research projects

2019 - 2023

Genetic and chemical ablation of senescent cells that result from age-dépendent telomere erosion

Lead researcher : Léa Harrington
Co-researchers : Michael David Tyers
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2016 - 2022

Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease

Lead researcher : Léa Harrington
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2014 - 2020

TELOMERE INTEGRITY AND STABILITY OF THE DIFFERENTIATED STATE

Lead researcher : Léa Harrington
Co-researchers : Dean Betts
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2015 - 2019

UNE APPROCHE CHIMIO- ET PROTEO-GENOMIQUE EN MEDECINE PERSONNALISEE POUR LA LEUCEMIE MYELOIDE AIGUE

Lead researcher : Guy Sauvageau
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds d'innovation
2011 - 2014

INVESTIGATION OF NOVEL METHODS OF TELOMERE MAINTENANCE IN CELLULAR SENESCENCE, AGING AND CANCER

Lead researcher : Léa Harrington
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs:

Outreach

Publications and presentations

Disciplines

  • Biochemistry