Les mécanismes de signalisation cellulaire sont essentiels pour que les cellules intègrent les signaux de l’environnement externe génèrent des réponses adaptées. La dérégulation de ces mécanismes par des mutations dans des protéines de signalisation entraînent diverses pathologies. L’un des exemples les plus létaux est le cancer, qui résulte souvent de mutations qui activent des proto-oncogènes (par exemple, KRAS, BRAF, PIK3CA) ou inactivent des gènes suppresseurs de tumeurs (par exemple, PTEN, APC, TP53). L’objectif principal du laboratoire Roux est de décoder les réseaux de signalisation au sein des cellules cancéreuses afin de faciliter le développement de nouveaux traitements anticancéreux

2024

The expanding landscape of canonical and non-canonical protein phosphorylation

Houles T, Yoon SO, Roux PP

Trends Biochem. Sci. 49, 986-999 (2024)

Immunotherapeutic targeting of surfaceome heterogeneity in AML

Bordeleau ME, Audemard E, Metois A, Theret L, Lisi V, Farah A, Spinella JF, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil E, Beliveau F, Pfammatter S, Feghaly A, Boucher G, Gendron P, Thibault P, Barabe F, Lemieux S, Richard-Carpentier G, Hebert J, Lavallee VP, Roux PP, Sauvageau G

Cell Rep. 43, 114260 (2024)

14-3-3 regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

Rial SA, You Z, Vivoli A, Sean D, Al-Khoury A, Lavoie G, Civelek M, Martinez-Sanchez A, Roux Pp, Durcan TM, Lim GE

bioRxiv (2024)

Plakoglobin regulates adipocyte differentiation independently of the Wnt/B-catenin signaling pathway

Abou Azar F, Mugabo Y, Yuen S, Del Veliz S, Pare F, Rial SA, Lavoie G, Roux PP, Lim GE

Biochim Biophys Acta Mol Cell Res. 1871, 119690 (2024)

Identification of RSK substrates using an analog-sensitive kinase approach

Lizcano-Perret B, Vertommen D, Herinckx G, Calabrese V, Gatto L, Roux PP, Michiels T

J Biol Chem. 300, 105739 (2024)

2023

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

Houles T, Boucher J, Lavoie G, MacLeod G, Lin S, Angers S, Roux PP

Cell Death Discov. 9, 459 (2023)

CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216

Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S

Blood Adv. Sep 20, Online ahead of print (2023)

HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer

Attalla SS, Boucher J, Proud H, Taifour T, Zuo D, Sanguin-Gendreau V, Ling C, Johnson G, Li V, Luo RB, Kuasne H, Papavasiliou V, Walsh LA, Barok M, Joensuu H, Park M, Roux PP, Muller WJ

Cancer Immunol. Res. 11, 1184-1202 (2023)

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lu Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D.

Nature Commun. 14, 3150 (2023)

2022

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean E, Guerin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP

Nature Commun. 13, 6457 (2022)

Proteomic analysis of the actin cortex in interphase and mitosis

Vadnjal N, Nourreddine S, Lavoie G, Serres M, Roux PP, Paluch EK

J. Cell Sci. 135, jcs259993 (2022)

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wunnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JS

JCI Insight 7, e154174 (2022)

CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells

Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau G

Blood Adv. 6, 3626-3631 (2022)

2021

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

Cerezo EL, Houles T, Lie O, Sarthou MK, Audoynaud C, Lavoie G, Halladjian M, Cantaloube S, Froment C, Burlet-Schiltz O, Henry Y, Roux PP, Henras AK, Romeo Y

PLoS Genet. 17, e1009583 (2021)

Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice

Madogwe E, Schuermann Y, Siddappa D, Bordignon V, Roux PP, Duggavathi R

Reproduction 161, 183-193 (2021)

2020

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

Aubert L, Nandagopal N, Roux PP

Mol. Cell. Oncol. 7, 1822123 (2020)

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

De Jamblinne CV, Decelle B, Dehghani M, Joseph M, Sriskandarajah N, Leguay K, Rambaud B, Lemieux S, Roux PP, Hipfner DR, Carreno S

J. Cell Biol. 219, e201911035 (2020)

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP

Nature Commun. 11, 3701 (2020)

An ErbB2 splice variant lacking exon 16 drives lung carcinoma

Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ

Proc. Natl Acad. Sci. USA 1, 202007474 (2020)

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Meant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jegou A, Romet-Lemonne G, Charras G

Nature Cell Biol. 22, 803-814 (2020)

NF45 and NF90 regulate mitotic gene expression by competing with Staufen-mediated mRNA decay

Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Meant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP

Cell Reports 31, 107660 (2020)

Controversies around the function of LARP1

Berman AJ*, Thoreen CC*, Dedeic Z, Chettle J, Roux PP*, Blagden SP*

RNA Biol. 1, 1-11 (2020)

F-Actin interactome reveals Vimentin as a key regulator of Actin organization and cell mechanics in mitosis

Serres MP, Samwer M, Truong Quang BA, Petronczki M, Roux PP*, Paluch EK*

Dev. Cell 52, 210-222 (2020)

Loss of DP1 aggravates vascular remodeling in pulmonary arterial hypertension via mTORC1 signaling

He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y

Am. J. Respir. Crit. Care Med. 1, 1-15 (2020)

Proteomic analysis reveals a role for RSK in p120-catenin phosphorylation and melanoma cell-cell adhesion

Meant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP

Mol. Cell. Proteomics 19, 50-64 (2020)