Comprendre les mécanismes qui permettent la reconstitution de l’ADN après qu’il ait été endommagé par les nombreux éléments chimiques présents dans l’environnement et ainsi améliorer les différents traitements pour les personnes cancéreuses qui doivent absorber des produits chimiques aux fins de la chimiothérapie.

Thèmes

• Chromosome biogenesis
• Nucleosome
• DNA repair
• Chromatin
• DNA damage
• Genome integrity
• Genomic instability
• Chemotherapy
• Antifungal therapy
• Vitamin B3
• Nocotinamide

Intérêts de recherche

• Chromatin assembly during DNA replication
• Links between chromatin assembly and the repair of DNA lesions caused by cancer chemotherapeutic agents
• Biological functions of histone acetylation and deacetylation
• Histone deacetylases as a novel targets for treatment

Discovered a novel feature of the chromosome cycle that plays an important role in the response to DNA damage causes by cancer chemotherapeutic agents

• Delgoshaie N, Tang X, Kanshin ED, Williams EC, Rudner AD, Thibault P, Tyers M (2014) and Verreault A. Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4. J. Biol. Chem. 289: 13186-13196.
• Jeffery, D., Kakusho, N., You, Z., Wyse, B., Gharib, M., Weinreich, M., Thibault, P., Verreault, A.,Masai, H. and Yankulov, K. (2014) Cdc28 is a major Chromatin Assembly Factor 1 kinase that regulates its association with chromatin; Cell Cycle 14: 74-85.
• Simoneau, A., Delgoshaie, N., Celic, I., Dai, J., Abshiru, N., Costantino, S., Thibault, P., Boeke, J.D., Verreault, A., and Wurtele, H. (2015) Interplay between histone H3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage. Genetics, 200: 185-205.
• Abshiru, N., Caron-Lizotte O., Rajan, R.E., Jamai, A., Pomiès, C., Verreault, A*., and Thibault, P.* (2015) Discovery of protein acetylation patterns by deconvolution of peptide isomer mass spectra. Nature Commun., 6: 8648*Co-corresponding authors.
• Sincennes, M.-C., Humbert, M., Grondin, B., Lisi, V., Haman, A., Cazaux C., Affar, el-B., Verreault, A. and Hoang, T. (2016) The LMO2 oncogene regulates DNA replication in hematopoietic cells. Proc. Natl. Acad. Sci. USA, 113: 1393-1398.