The work of Dr Séguin bears on the cognitive and emotional aspects of the development of mental health, while taking into account risk and protective factors for substance use and cardiovascular health. His clinical training allows him to work as much with cognitive schemas, information processing approaches and underlying neural functions. His doctoral work (McGill University, 1995) aimed largely at neuropsychological aspects of physical aggression. Subsequent work broadened that conceptual basis to encompass hyperactivity, other externalised and internalised problems as well as cognitive development. A longitudinal study of a birth cohort allowed to examine the eraly development of self-regulation from a cognitive point of view. More recent studies, include pregnancy cohorts. One important hypothesis suggests that self regulation is partly acquired through socialisation. This research investigates the physiological, genetic and both physical and social environnemental bases of that learning from pregnancy. Child characteristics of interest include neuropsychological function as well as early temperament and personality. A key question for rpevention is what are the challenges and resources that affect that development? How does early self regulation lead to mental health? Can early interventions which aim to support families have an imppact on self-regulation?

1. **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Renaud, J., Tremblay, R.E., & Séguin, J.R. (2021). Association between recurrent dreams, disturbing dreams and suicidal ideation in adolescents. Dreaming
2. *London-Nadeau, K., Rioux, C., Vitaro, F., Côté, S.M., Boivin, M., Tremblay, R.E., Séguin, J.R., Castellanos-Ryan, N. (2021). Longitudinal associations of cannabis, depression and anxiety in heterosexual and LGB adolescents. Journal of Abnormal Psychology.
3. Cox, S.M.L., Castellanos-Ryan, N., Parent, S., Benkelfat, C., Vitaro, F., Pihl, R.O., Boivin, M., Tremblay, R.E., Leyton, M., Séguin, J.R. (2021). Externalizing risk pathways for adolescent substance use and its developmental onset: A Canadian birth cohort study. Canadian Journal of Psychiatry.
4. *Suffren, S., *La Buissonière-Ariza, V., Tucholka, A., Nassim, M., Séguin, J.R., Boivin, M., Singh, M.K., Foland-Ross, L.R., Lepore, F., Gotlib, I.H., Tremblay, R.E., Maheu, F.S. (2021). Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood. Development and Psychopathology.
5. *Azar, N., Booij, L., Muckle, G., Arbuckle, T.E., Séguin, J.R., Asztalos, E., Fraser, W.D., Lanphear, B.P., Bouchard, M.F. (2021). Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Cognitive Ability in Early Childhood. Environment International, 146 https://doi.org/10.1016/j.envint.2020.106296
6. **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Tremblay, R.E., and Séguin, J.R. (2020). The relation between disturbing dreams and psychosocial maladjustment in children: A prospective study of the moderating role of early negative emotionality. Frontiers in Neurology, 11:762, 1-11. https://www.frontiersin.org/articles/10.3389/fneur.2020.00762/
7. Cox, S.M.L., Tippler, M., *Jaworska, N., Smart, K., Castellanos-Ryan, N., Durand, F., Allard, D., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). mGlu5 receptor availability in youth at risk for addictions: Effects of vulnerability traits and cannabis use. Neuropsychopharmacology. https://www.nature.com/articles/s41386-020-0708-x.pdf
8. *Orri, M., Séguin, J. R., Castellanos-Ryan, N., Tremblay, R. E., Côté, S. M., Turecki, G., Geoffroy, M.-C. (2020). A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0785-6
9. *Orri, M., *Scardera, S., *Perret, L.C., **Bolanis, D., Temcheff, C., Séguin, J.R., Boivin, M., Turecki, G., Tremblay, R.E., Côté, S.M., Geoffroy, M.C. (2020). Mental health problems and risk of suicidal ideation and attempts in adolescents. Pediatrics, 146(1), e20193823. https://doi.org/10.1542/peds.2019-3823
10. *Jaworska, N., Cox, S.M.L., Tippler, M., Castellanos-Ryan, N., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). Extra-striatal D2/3 receptor availability in youth at risk for addiction. Neuropsychopharmacology, 45(9), 1498-1505. https://www.nature.com/articles/s41386-020-0662-7
11. **Bolanis, D., Orri, M., Castellanos-Ryan, N., Renaud, J., Montreuil, T., Boivin, M., Vitaro, F., Tremblay, R.E., Turecki, G., Côté, S.M., Séguin, J.R., Geoffroy, M.C. (2020). Cannabis use, depression and suicidal ideation in Canadian adolescents: Comorbidity and direction of associations. Journal of Affective Disorders, 274, 1076-1083. https://doi.org/10.1016/j.jad.2020.05.136.
12. *Afzali, M. H., Stewart, S. H., Séguin, J. R., & Conrod, P. J. (2020). The network constellation of personality and substance use: Evolution from early to late adolescence. European Journal of Personality. https://doi.org/10.1002/per.2245
13. Oulhote, Y., Lanphear, B., Braun, J.M., Webster, G.M., Arbuckle, T.E., Etzel, T., Forget-Dubois, N., Séguin, J.R., Bouchard, M.F., MacFarlane, A., Ouellet, E., Fraser, W.D., Muckle, G. (2020). Gestational exposures to phthalates and folic acid, and autistic traits in Canadian children. Environmental Health Perspectives, 128, 2, https://ehp.niehs.nih.gov/doi/10.1289/EHP5621.
14. *Paquin, C., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter? PLoS One, 15, e0227179. https://doi.org/10.1371/journal.pone.0227179.
15. Krzeczkowski, J. E., Boylan, K., Arbuckle, T. E., Muckle, G., Poliakova, N., Séguin, J. R., Favotto, L.A., Savoy, C., Amani, B., Mortaji, N.; Van Lieshout, R.J. (2020). Maternal pregnancy diet quality is directly associated with autonomic nervous system function in 6-month-old offspring. The Journal of Nutrition, 150, 267-275 https://doi.org/10.1093/jn/nxz228
16. *Paquin, C., Castellanos-Ryan, N., Vitaro, F., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depression symptoms, child behavior problems and their transactional relations: Probing the role of formal childcare. Development and Psychopathology, 32(3), 831-844. https://doi.org/10.1017/S0954579419000956
17. *Charrois, J., Côté, S.M., Paquin, S., Séguin, J.R., Japel, C., Vitaro, F., Kim-Cohen, J., Tremblay, R.E., Herba, C.M. (2019). Maternal depression in early childhood and child emotional and behavioral outcomes at school-age: Examining the roles of preschool childcare quality and current maternal depression symptomatology. European Child and Adolescent Psychiatry, 29(5), 637-648. https://link.springer.com/article/10.1007%2Fs00787-019-01385-7
18. Rioux,C., *Murray,J., Castellanos-Ryan,N., Séguin,J.R., Tremblay,R.E., Parent,S. (2020). Moderation of parenting by inhibitory control in the prediction of the common and unique variance of hyperactivity-impulsivity and inattention. Development and Psychopathology, 32(3), 909-921. https://doi.org/10.1017/S0954579419000774
19. Arbuckle, T.E., MacPherson, S., Barrett, E., Muckle, G., Séguin, J.R., Foster, W.G., Sathyanarayana, S., Dodds, L., Fisher, M., Agarwal, A., Monnier, P., Walker, M., Fraser, W.D. (2019). Do stressful life events during pregnancy modify associations between phthalates and anogenital distance in newborns? Environmental Research, 177, 108593. http://www.sciencedirect.com/science/article/pii/S0013935119303901, https://doi.org/10.1016/j.envres.2019.108593
20. *La Buissonnière-Ariza V., Séguin, J.R., Nassim, M., Boivin, M., Pine, D.S., Lepore, F., Tremblay, R.E., Maheu, F.S. (2019). Chronic Harsh Parenting and Anxiety Associations with Fear Circuitry Function in Healthy Adolescents: A Preliminary Study. Biological Psychology, 145, 198-210. http://www.sciencedirect.com/science/article/pii/S0301051118301248 https://doi.org/10.1016/j.biopsycho.2019.03.019
21. *Gorin, H. M., Kosson, D. S., Miller, S. A., Fontaine, N. M. G., Vitaro, F., Séguin, J. R., Boivin, M., Côté, S. & Tremblay, R. E. (2019). Psychopathic Traits in Middle Childhood: Evidence of a Hierarchical Three-Factor Structure. Journal of Psychopathology and Behavioral Assessment, 41, 341-352. https://doi.org/10.1007/s10862-019-09733-2
22. *Farooqi, N. A. I., *Scotti, M., Yu, A., Lew, J., Monnier, P., Botteron, K. N., Campbell, B.C., Booij, L., Herba, C.M., Séguin, J.R., Castellanos-Ryan, N., McCracken, J.T., Nguyen, T.V. (2019). Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits. Journal of Neuroendocrinology, 31, e12682. https://doi.org/10.1111/jne.12682
23. *Smart, K., Cox, S. M. L., Kostikov, A., Shalai, A., Scala, S. G., Tippler, M., *Jaworska, N., Boivin, M., Séguin, J. R., Benkelfat, C., Leyton, M. (2019). Effect of (z)-isomer content on [¹¹C]ABP688 binding potential in humans. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1175-1178. https://link.springer.com/article/10.1007/s00259-018-4237-3
24. *Smart, K., Cox, S. M. L., Scala, S. G., Tippler, M., *Jaworska, N., Boivin, M., Séguin, J. R., Benkelfat, C., Leyton, M. (2019). Sex differences in [¹¹C]ABP688 Binding A positron emission tomography study of mGlu5 receptors. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1179-1183. https://link.springer.com/article/10.1007/s00259-018-4252-4
25. *Afzali, M. H., Sunderland, M., Stewart, S. H., Mâsse, B., Séguin, J. R., Newton, N., Teeson, M., Conrod, P. J. (2019). Machine-learning prediction of adolescent alcohol use: A cross-study, cross-cultural validation. Addiction, 114(4), 662-671. https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14504
26. **Rioux, C., Castellanos-Ryan, N. Vitaro, F., Séguin, J.R. (2019). The interactive effects of parental knowledge with impulsivity and sensation seeking in adolescent substance use. Child Psychiatry and Human Development, 50, 95-107. https://link.springer.com/article/10.1007/s10578-018-0825-5
27. **Rioux, C., & Séguin, J. R. (2019). Commentary on Otten et al. (2019): Moderators and person-environment interactions in developmental cascade models. Addiction, 114(2), 335-336.
28. *Sharkey, R.J., *Bourque, J, Larcher, K., Misic, B., Zhang, Y., Altinkaya, A., Sadikot, A., Conrod, P.J., Evans, A.C., Garavan, H., Leyton, M., Séguin, J.R., Pihl, R.O., Dagher, A. (2019). Early adolescent striatal and midbrain resting state connectivity correlate with impulsivity, sensation-seeking, and body weight. Appetite, 132, 25-36. https://www.sciencedirect.com/science/article/pii/S0195666318306184?via%3Dihub
29. Li, N., Arbuckle, T.E., Muckle, G., Lanphear, B.P., Boivin, M., Chen, A., Dodds, L., Fraser, W.D., Ouellet, E., Séguin, J.R., Vélez, M.P., Yolton, K., Braun, J.M. (2019). Associations of cord blood leptin and adiponectin with children’s cognitive abilities. Psychoneuroendocrinology, 99, 257-264. https://www.sciencedirect.com/science/article/pii/S0306453018308187?via%3Dihub https://doi.org/10.1016/j.psyneuen.2018.10.021
30. Parent, S., Lupien, S., Herba, C., Dupéré, V., Gunnar, M., and Séguin, J.R. (2019). Children’s cortisol response to the transition from preschool to formal schooling: A review. Psychoneuroendocrinology, 99, 196-205. https://doi.org/10.1016/j.psyneuen.2018.09.013.
31. *Morin, J.-F. G., *Afzali, M. H., *Bourque, J., Stewart, S. H., Séguin, J. R., *O'Leary-Barrett, M. & Conrod, P. J. (2019) A population-based analysis of the relationship between substance use and adolescent cognitive development. American Journal of Psychiatry, 176, 98-106. https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18020202#
32. **Rioux, C., Séguin, J.R., Paris, J. (2018). Perspective: Differential susceptibility to the environment and Borderline Personality Disorder. Harvard Psychiatry Review, 26(6), 374-383. https://doi.org/10.1097/HRP.0000000000000182.
33. Etzel, T., Muckle, G., Arbuckle, T. E., Fraser, W. D., Ouellet, E., Séguin, J. R., Lanphear, B., Braun, J.M. (2018). Prenatal urinary triclosan concentrations and child neurobehavior. Environment International, 114, 152-159. https://www.sciencedirect.com/science/article/pii/S0160412017319979